Abstract #3944

Accurate High-speed 3D-Registration of EPI vNavs for Head Motion Correction

Yingzhuo Zhang¹, Iman Aganj^2,3, André J.W. van der Kouwe^2,3, and Matthew Dylan Tisdall⁴

¹John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Low-resolution, whole-head volumes can be acquired rapidly with EPI-based volumetric navigators (vNavs). vNavs interspersed in a longer scan are widely used for prospective motion correction in a variety of sequences. To further improve the accuracy and flexibility of vNavs, we present a novel registration algorithm, tailored specifically for the vNavs application. Accuracy of the algorithm is tested on navigator volumes acquired with human volunteers at three isotropic resolutions, 6.4mm, 8mm, and 10mm, using a series of field of view (FOV) rotations and translations to provide ground truth rigid “motion”.

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