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Abstract #4048

Systematic Differences in High Angular Resolution Diffusion Imaging at Baseline in a Multicenter Longitudinal Clinical Trial

Ken Sakaie1, Xiapeng Zhou1, Josef Debbins2, Mark Lowe1, and Robert Fox1

1The Cleveland Clinic, Cleveland, OH, United States, 2Keller Center for Imaging Innovation, Barrow Neurological Institute, Phoenix, AZ, United States

The lack of imaging biomarkers is a key obstacle to the development of treatment for progressive multiple sclerosis. While diffusion MRI is a promising biomarker, variability among scanners may limit its use. We examine site-related variability among multiple sclerosis patients to inform the design of multicenter trials.

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