Abstract #4051

LONGITUDINAL ASSESSMENT OF LARGE-SCALE BRAIN FUNCTIONAL NETWORKS IN PATIENTS WITH MS: RELATIONSHIP WITH CLINICAL DISABILITY AND COGNITIVE IMPAIRMENT

Paola Valsasina¹, Maria Assunta Rocca¹, Fiammetta Pirro¹, Annalisa Colombi¹, Elisabetta Pagani¹, Ermelinda De Meo¹, Bruno Colombo², Paolo Preziosa¹, Vittorio Martinelli², Giancarlo Comi², Andrea Falini³, and Massimo Filippi¹

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Aim of this study was to investigate the temporal evolution of resting state (RS) functional connectivity (FC) in patients with multiple sclerosis (MS) and its correlation with clinical and cognitive worsening. The predictive value of baseline functional network measures on the worsening of clinical disability/cognitive impairment was also explored. No significant RS FC changes were detected in healthy controls, while MS patients showed a complex pattern of longitudinal changes in the different networks, with a trend towards an increase (or stability) of RS FC in clinically stable MS patients, and a decrease of RS FC in clinically worsened MS patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.