Abstract #4053

A longitudinal study of the effect of Multiple Sclerosis on surrounding white matter using z-spectrum imaging at 7T

Kingkarn Aphiwatthanasumet¹, Olivier Mougin¹, Nick Geades¹, Nikos Evangelou², Richard Bowtell¹, and Penny Gowland¹

¹Physics and Astronomy, Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Neurology, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom

MS lesions are known to evolve in time, many showing signs of remyelination. To investigate this, we considered the changes in the regions around existing lesions of varying ages, to test the hypothesis that there is ongoing tissue damage in the regions around white matter lesions in MS. We found that the quantitative MT measured at 7T values in the region surrounding MS lesions decreased over the period of a longitudinal 6 month study. No systematic trend was found for the lesion core. This supports the hypothesis that an MS lesion causes ongoing damage in the region surrounding the lesion.

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