Abstract #4056

A preliminary study: the Values of Quantitative Susceptibility Mapping (QSM) in CIS and MS in Children

Hua CHENG¹, Hong ZHANG¹, Yang FAN², TongLi HAN³, Yue LIU¹, and Yun PENG¹

¹Imaging Center, Beijing Children's Hospita, Capital Medical University, Beijing, People's Republic of China, ²MR Research China, GE Healthcare, ³Neurology Department, Beijing Children's Hospita, Capital Medical University, Beijing, People's Republic of China

Quantitative Susceptibility Mapping (QSM) has been well used in evaluating the iron quantity changes in adult patients with multiple sclerosis (MS). However, it has not been tested in pediatric MS patients. In the present study, QSM was applied to assess difference of iron quantity in clinically isolated syndrome (CIS) and MS in children. It is shown that QSM provides a superior sensitivity method in the detection iron of changes of MS-related tissue in children, which suggests that QSM may serve as a potential sensitive biomarker in pediatric MS.

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