Abstract #4059

Toward a standardized quantitative imaging protocol for multiple sclerosis: a multisite study of magnetization transfer and quantitative T1 imaging techniques

Ian Tagge¹, Daniel Schwartz¹, Katherine Powers¹, Rohit Bakshi², Peter Calabresi³, Todd Constable⁴, John Grinstead^1,5, Roland Henry⁶, Govind Nair⁷, Jiwon Oh^3,8, Li Pan⁹, Nico Papinutto⁶, Daniel Pelletier¹⁰, Daniel S Reich⁷, Nancy Sicotte¹⁰, Jack Simon¹, William Stern⁶, and William Rooney¹¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Brigham & Women's Hospital, Harvard Medical School, ³Johns Hopkins, ⁴Yale, ⁵Siemens Medical Solutions, Portland, OR, ⁶University of California San Francisco, ⁷National Institute of Neurological Disease and Stroke, National Institute of Health, ⁸University of Toronto, ⁹Siemens Healthcare, Baltimore, MD, ¹⁰University of Southern California, Keck School of Medicine, ¹¹Oregon Health & Science University, Portland, OR, United States

The current lack of standardization in MRI protocols leads to increased variability, particularly in semi-quantitative techniques such as MTR, and makes comparisons between studies almost impossible. A single subject with clinically stable RRMS travelled to seven North American sites and underwent two distinct 3T MRI sessions following a standardized MTR and qT₁ protocol at each site. Both MTR and qT₁ mapping have been shown to have potential in elucidating tissue characteristics and underlying pathology. This work demonstrated that use of carefully standardized protocols produces consistent quantitative and semi-quantitative measurements across sites in MS brain tissue in-vivo.

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