Attention deficit hyperactivity disorder (ADHD) is a most common developmental disorders in both children and adult population. However, the treatment for ADHD remains limited. To investigate the effects of taurine on ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted in this study. The functional brain signals including functional connectivity (FC) and mean amplitude of low-frequency fluctuation (mALFF) were detected by using resting-state functional magnetic resonance imaging (rs-fMRI). Our findings in FC and mALFF suggested that taurine administration probably improves the hyperactive behavior in ADHD by changing brain functional signals in SHR rats.