Abstract #4078

Effects of taurine on resting-state fMRI activity in rat model of attention deficit hyperactivity disorder

Hong-Chun Chou¹, Bor-Show Tzang², Vincent Chin-Hung Chen^3,4, and Jun-Cheng Weng^1,5

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, ³School of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Attention deficit hyperactivity disorder (ADHD) is a most common developmental disorders in both children and adult population. However, the treatment for ADHD remains limited. To investigate the effects of taurine on ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted in this study. The functional brain signals including functional connectivity (FC) and mean amplitude of low-frequency fluctuation (mALFF) were detected by using resting-state functional magnetic resonance imaging (rs-fMRI). Our findings in FC and mALFF suggested that taurine administration probably improves the hyperactive behavior in ADHD by changing brain functional signals in SHR rats.

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