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Abstract #4078

Effects of taurine on resting-state fMRI activity in rat model of attention deficit hyperactivity disorder

Hong-Chun Chou1, Bor-Show Tzang2, Vincent Chin-Hung Chen3,4, and Jun-Cheng Weng1,5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, 3School of Medicine, Chang Gung University, Taoyuan, Taiwan, 4Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 5Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Attention deficit hyperactivity disorder (ADHD) is a most common developmental disorders in both children and adult population. However, the treatment for ADHD remains limited. To investigate the effects of taurine on ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted in this study. The functional brain signals including functional connectivity (FC) and mean amplitude of low-frequency fluctuation (mALFF) were detected by using resting-state functional magnetic resonance imaging (rs-fMRI). Our findings in FC and mALFF suggested that taurine administration probably improves the hyperactive behavior in ADHD by changing brain functional signals in SHR rats.

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