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Abstract #4086

Mapping and modulation of Down Syndrome specific functional network in Dp(16)1yey mouse model

Laura-Adela Harsan1,2,3, Meltem Karatas1, Thu Lan NGUYEN4, Anna Mechling3, Tanzil Arefin 3, Thomas Bienert3, Hsu-Lei Lee3, Dominik von Elverfeldt3, and Yann Herault4

1Engineering science, computer science and imaging laboratory (ICube), University of Strasbourg-CNRS France, Strasbourg, France, 2Biophysics and Nuclear Medicine, Faculty of Medicine and University Hospital, Strasbourg, Strasbourg, France, 3Medical Physics, AMIR, University Hospital, Freiburg, Freiburg, GA, Germany, 4Translational medicine and neurogenetics, Institute of Genetics and Molecular Imaging, University of Strasbourg

Resting state functional MRI (rsfMRI) is currently the only non-invasive approach capable of giving insight into the large-scale cerebral networks architecture and its dynamic changes in pathology or following therapeutic interventions. With the aim of deciphering specific network signatures underlying memory and cognitive impairments in Down Syndrome pathology, we performed rsfMRI and network analysis in the Dp(16)1yey mouse model. We found perturbed synchrony of BOLD-signal in the hippocampal network of Dp(16)1yey mice. We further modulated this memory specific cerebral circuitry via therapeutic treatment with a DYRK1A kinase inhibitor, aimed at rescuing the memory and cognitive dysfunctions characterizing this mouse model.

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