Abstract #4088

Preclinical detection of leptomeningeal inflammation using contrast-enhanced FLAIR at 9.4T in the EAE-MOG mouse model of Multiple Sclerosis

Nicola Bertolino¹, Suyog Pol¹, Robert Zivadinov^1,2, Natan Babek¹, Michelle Sudyn¹, Michele Sveinsson¹, Danielle Siebert¹, Marilena Preda^1,2, Dhaval Shah¹, and Ferdinand Schweser^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

Persistent clusters of inflammatory cells in the leptomeningeal compartment are thought to contribute directly to subpial cortical demyelination and neurodegeneration in MS patients. In human patients, post-contrast 3D T2-FLAIR allows the detection of leakage of contrast agent into inflammatory foci and the subarachnoid space. We propose a pulse sequence for LMI imaging in rodents and demonstrate its applicability in the EAE-MOG model of MS at 9.4T.

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