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Abstract #4090

Application of multiphase pseudo-continuous ASL for quantitative blood flow measurement in rat brain metastasis

Manon A. Simard1, James R. Larkin1, Alexandre A. Khrapitchev1, Kevin J. Ray1, Michael A. Chappell2, and Nicola R. Sibson1

1CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Arterial spin labelling (ASL) MRI is a useful clinical method of measuring blood flow in brain disorders such as tumours. This work presents a pre-clinical assessment of cerebral blood flow (CBF) by pseudo-continuous ASL in progressing rat breast cancer brain metastases. A statistically significant decrease in CBF of brain metastases was readily observed when tumours had grown sufficiently to breach the blood brain barrier, allowing gadolinium enhancement in T1-weighted images. Upon histological analysis, the brain metastases proved to be hypoxic, consistent with a reduction in CBF in those regions.

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