Abstract #4090

Application of multiphase pseudo-continuous ASL for quantitative blood flow measurement in rat brain metastasis

Manon A. Simard¹, James R. Larkin¹, Alexandre A. Khrapitchev¹, Kevin J. Ray¹, Michael A. Chappell², and Nicola R. Sibson¹

¹CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ²Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Arterial spin labelling (ASL) MRI is a useful clinical method of measuring blood flow in brain disorders such as tumours. This work presents a pre-clinical assessment of cerebral blood flow (CBF) by pseudo-continuous ASL in progressing rat breast cancer brain metastases. A statistically significant decrease in CBF of brain metastases was readily observed when tumours had grown sufficiently to breach the blood brain barrier, allowing gadolinium enhancement in T₁-weighted images. Upon histological analysis, the brain metastases proved to be hypoxic, consistent with a reduction in CBF in those regions.

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