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Abstract #4095

Developmental Susceptibility changes from neonate to early childhood using Quantitative Susceptibility Mapping (QSM)

Takuya Hinoda1, Yasutaka Fushimi1, Tomohisa Okada1,2, Akira Yamamoto1, Tsutomu Okada1, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear medicine, Graduate school of Medicine, Kyoto University, Kyoto, Japan, 2Human Brain Research Center, Graduate School of Medicine, Kyoto University

To assess the susceptibility changes in early childhood (0 45 months) and these consistencies with previous reports. In our study, 35 children were enrolled and QSM was calculated from 3D gradient-echo images. Susceptibility values in deep gray matter structures showed positive correlation with the subjects’ age and theoretical iron contents, and these in white matter structures showed negative correlation in posterior peduncle of internal capsule and optic radiation. These results reflect the normal neural development in the early childhood and QSM can provide us quantitative methods to evaluate brain development.

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