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Abstract #4100

Axon development revealed by directional diffusivities in intra-axonal and extra-axonal compartments

Xianjun Li1,2, Miaomiao Wang1, Heng Liu1,2, Jie Gao1, Xiaocheng Wei3, and Jian Yang1

1Department of Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China, 2Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China, 3MR Research China, GE Healthcare, Bei Jing, People's Republic of China

White matter in human brain undergoes a complex and long lasting process. It is not likely that conventional diffusion parameters are specific enough to distinguish axon-related and myelin-related processes. This study investigates directional diffusivities in intra-axonal and extra-axonal compartments on preterm neonates, term neonates, infants, and adults. Two change patterns of extra-axonal axial and radial diffusivities are found during development. This may be related to premyelination and myelination. Developmental changes of the fiber dispersion and intra-axonal diffusivities are observed in both pre-myelination and myelination periods. Directional diffusivities in intra-axonal and extra-axonal compartments provide more detailed information to evaluate axonal development.

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