Retrospective study of MRI brains with volumetric measurements done using voxel based morphology was conducted for children with seizures imaged in KK Women’s and Children’s Hospital since 2006. There was decreased cerebral volume and increased ventricular volume in children with hippocampal abnormalities compared to children with structurally normal brain, the difference in volumes exceeding 1 standard deviation, not statistically significant likely on account of the small sample sizes. Relative reduced grey matter to white matter is seen in children with hippocampal abnormalities as well as in children with neuronal migration abnormalities, reaching statistical significance in both groups.
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