Abstract #4114

CEREBELLAR TRACTOGRAPHY STUDY ON ADOLESCENT IDIOPATHIC SCOLIOSIS

Cindy Xue¹, Lin Shi², Steve C.N Hui¹, Tsz-ping Lam³, Bobby K.W Ng³, Jack C.Y Cheng³, and Winnie C.W Chu⁴

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine and Therapeutics, The Chinese University of Hong Kong, ³Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, ⁴Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong

Adolescent Idiopathic Scoliosis (AIS) is a 3-dimensional spinal deformity which occurs predominantly in adolescent girls. Impaired postural balance and tonsillar ectopia are reported findings in AIS. This study sought to investigate and compare white matter integrity of the cerebellar pathways in AIS with matched controls. Anatomically-guided deterministic tractography was used to reconstruct the cerebellar pathways. Lower FA value was found in spinocerebellar tract and in intracerebellar tract in AIS, suggestive of, reduced white matter integrity of the cerebellar pathway, which is in agreement with similar changes in other white matter pathways within the brain of AIS patients.

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