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Abstract #4124

Towards automated MP2RAGE-based hippocampal volumetry for routine clinical practice

Bénédicte Maréchal1,2,3, Sophie Espinoza4, Wadie Ben Hassen5, Tobias Kober1,2,3, Christophe Habas4, and Alexis Roche1,2,3

1Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI PI, Lausanne, Switzerland, 2Department of Radiology, CHUV, Lausanne, Switzerland, 3LTS5, EPFL, Lausanne, Switzerland, 4Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, Paris, France, 5Siemens Healthcare S.A.S., Saint-Denis, France

We investigate the potential of an automated method to provide hippocampal volume estimates using T1-weighted images obtained from the MP2RAGE sequence. Scheltens visual medial temporal atrophy scores from 27 patients undergoing clinical brain MRI for workup of cognitive decline were compared to automated volumetric measures using multinomial logistic regression. Strong correlation was observed which suggests that the employed hippocampal volumetry method may help supporting diagnosis of neurodegenerative diseases.

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