Abstract #4124

Towards automated MP2RAGE-based hippocampal volumetry for routine clinical practice

Bénédicte Maréchal^1,2,3, Sophie Espinoza⁴, Wadie Ben Hassen⁵, Tobias Kober^1,2,3, Christophe Habas⁴, and Alexis Roche^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI PI, Lausanne, Switzerland, ²Department of Radiology, CHUV, Lausanne, Switzerland, ³LTS5, EPFL, Lausanne, Switzerland, ⁴Service de NeuroImagerie, Centre Hospitalier National d'Ophtalmologie des XV-XX, Paris, France, ⁵Siemens Healthcare S.A.S., Saint-Denis, France

We investigate the potential of an automated method to provide hippocampal volume estimates using T1-weighted images obtained from the MP2RAGE sequence. Scheltens visual medial temporal atrophy scores from 27 patients undergoing clinical brain MRI for workup of cognitive decline were compared to automated volumetric measures using multinomial logistic regression. Strong correlation was observed which suggests that the employed hippocampal volumetry method may help supporting diagnosis of neurodegenerative diseases.

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