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Abstract #4131

Changes in susceptibility-weighted MRI contrast reflect differences in cortical spreading of pathology in early-onset and late-onset Alzheimer patients

Marjolein Bulk1,2, Boyd Kenkhuis1, Linda M. van der Graaf1,2, Ingrid M. Hegeman3, Mark A. van Buchem1, Remco Natté3, and Louise van der Weerd1,2

1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Pathology, Leiden University Medical Center, Leiden, Netherlands

Changes in susceptibility-based MRI contrast and histological correlates of post-mortem brain tissue have been used to distinguish differences in spreading patterns of AD pathology over the cortex between AD subtypes. Susceptibility-based MRI allowed us to clearly distinguish early-onset and late-onset AD patients. The MRI contrast in the different regions closely reflected the overall severity of pathology. This study confirms iron deposition as the underlying source of MRI contrast in all cortical regions, and demonstrates that iron deposition is a putative biomarker for disease progression, with a spatial and temporal spreading pattern independent of amyloid and tau.

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