Changes in susceptibility-based MRI contrast and histological correlates of post-mortem brain tissue have been used to distinguish differences in spreading patterns of AD pathology over the cortex between AD subtypes. Susceptibility-based MRI allowed us to clearly distinguish early-onset and late-onset AD patients. The MRI contrast in the different regions closely reflected the overall severity of pathology. This study confirms iron deposition as the underlying source of MRI contrast in all cortical regions, and demonstrates that iron deposition is a putative biomarker for disease progression, with a spatial and temporal spreading pattern independent of amyloid and tau.
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