Abstract #4133

3D DCE-MR imaging shows compromised brain waste transport in spontaneously hypertensive rats

Kristian Nygaard Mortensen¹, Simon Sanggaard¹, Hedok Lee², Palle Koch³, Maiken Nedergaard^1,4, Bjørn Quistorff³, and Helene Benveniste²

¹Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark, ²Department of Anesthesiology, Yale University, New Haven, CT, United States, ³Cellular and Metabolic Research & NMR, University of Copenhagen, Copenhagen, Denmark, ⁴Department of Neurosurgery, University of Rochester, Rochester, NY, United States

The link between hypertension and cerebral small vessel disease is key to understanding pathobiology of certain types of dementia. We studied the effects of mild hypertension on a newly discovered pathway for clearance of solutes from the brain parenchyma in young spontaneously hypertensive rats using DCE-MRI after intrathecal infusion of a paramagnetic contrast agent. We found normal-to-increased tracer influx and decreased efflux to and from the brain parenchyma, consistent with a lowered efficiency of brain solute clearance. This suggests that a compromised brain waste transport system may be implicated in the development of cerebral small vessel disease and dementia.

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