Meeting Banner
Abstract #4133

3D DCE-MR imaging shows compromised brain waste transport in spontaneously hypertensive rats

Kristian Nygaard Mortensen1, Simon Sanggaard1, Hedok Lee2, Palle Koch3, Maiken Nedergaard1,4, Bjørn Quistorff3, and Helene Benveniste2

1Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark, 2Department of Anesthesiology, Yale University, New Haven, CT, United States, 3Cellular and Metabolic Research & NMR, University of Copenhagen, Copenhagen, Denmark, 4Department of Neurosurgery, University of Rochester, Rochester, NY, United States

The link between hypertension and cerebral small vessel disease is key to understanding pathobiology of certain types of dementia. We studied the effects of mild hypertension on a newly discovered pathway for clearance of solutes from the brain parenchyma in young spontaneously hypertensive rats using DCE-MRI after intrathecal infusion of a paramagnetic contrast agent. We found normal-to-increased tracer influx and decreased efflux to and from the brain parenchyma, consistent with a lowered efficiency of brain solute clearance. This suggests that a compromised brain waste transport system may be implicated in the development of cerebral small vessel disease and dementia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here