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Abstract #4147

Altered Topological Properties of Structural Connectome in Early-Stage, Drug-naive PD Revealed by Graph Theoretical Analysis

Xueling Suo1, Du Lei2, Nannan Li3, Lan Cheng3, Lei Li1, Fuqin Chen4, Meiyun Wang5, Rong Peng3, and Qiyong Gong1

1Radiology, West china hospital, Chengdu, People's Republic of China, 2Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, 3Neurology, West china hospital, People's Republic of China, 4Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, People's Republic of China, 5Radiology, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, People's Republic of China

To use diffusion tensor imaging (DTI) and graph theory approaches to explore the brain structural connectome in patients with early-stage drug-naive Parkinson's disease (PD). The structural connectome was constructed by using deterministic tractography and thresholding the mean fractional anisotropy of 90 brain regions to yield 90*90 partial correlation matrixes. The decreased characteristic path length Lp and increased global efficiency Eglob in the PD patients relative to healthy controls indicated that structural networks are closer to randomization, providing a structural basis for functional alterations of PD.

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