The recently discovered glymphatic system has fundamentally altered the traditional model of cerebrospinal fluid (CSF) hydrodynamics and shown promising results in applications for understanding neurological diseases1, 2. However, little is known how diabetes affects the glymphatic system. The current study is the first investigation of the effect of diabetes on the glymphatic system and the relationship between glymphatic system and cognitive impairment in diabetic rats using MRI and fluorescence imaging.
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