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Abstract #4159

Imaging Impairment of the Glymphatic System after Diabetes

Quan Jiang1,2, Li Zhang1, Guangliang Ding1, Esmaeil Davoodi-Bojd1, Qingjiang Li1, Lian Li1, David Hearshen3, Michael Chopp1,2, and Zhenggang Zhang1

1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Physics, Oakland University, Rochester, MI, United States, 3Radiology, Henry Ford Health System, Detroit, MI, United States

The recently discovered glymphatic system has fundamentally altered the traditional model of cerebrospinal fluid (CSF) hydrodynamics and shown promising results in applications for understanding neurological diseases1, 2. However, little is known how diabetes affects the glymphatic system. The current study is the first investigation of the effect of diabetes on the glymphatic system and the relationship between glymphatic system and cognitive impairment in diabetic rats using MRI and fluorescence imaging.

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