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Abstract #4188

Brain Structural Network of Working Memory and Processing Speed for ALL Survivors

Junyu Guo1, John O. Glass1, JungWon Hyun1, Yimei Li1, Heather Conklin1, Lisa Jacola1, Ching-Hon Pui1, Sima Jeha1, and Wilbrun E. Reddick1

1St Jude Children's Research Hospital, Memphis, TN, United States

Acute lymphoblastic leukemia survivors may have significant deficits in processing speed and working memory even when treated with only chemotherapy. We investigate the relationship of diffusion tensor imaging metrics in an a priori brain structural network with neurocognitive functions such as processing speed and working memory. We found that fractional anisotropy values in the structural network were significantly positively associated with processing speed performance in two MR exams two years apart, and axial diffusivity values were negatively associated with working memory in the MR exam at the end of therapy. These findings may provide potential evidence for a structural neurocognitive network.

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