Abstract #4196

Magnetic Resonance Imaging of Myelin Water: Principles and Applications

Cornelia Laule^1,2,3, Irene M. Vavasour¹, Shannon H. Kolind^1,4, Thorarin A. Bjarnason^1,5,6, Jing Zhang¹, Donna J.M. Lang¹, Hanwen Liu^3,7, Emil Ljungberg⁴, Roger Tam¹, Erin L. MacMillan⁴, John K. Kramer^3,8, Sandra Sirrs⁴, Piotr Kozlowski^1,3,7, Alexander Rauscher^1,9, Lara Boyd¹⁰, G.R. Wayne Moore^2,3,4, Anthony L. Traboulsee⁴, David K.B. Li^1,4, and Alexander L. MacKay^1,7

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, ⁴Medicine, University of British Columbia, Vancouver, BC, Canada, ⁵Interior Health, Kelowna, BC, Canada, ⁶Computer Science, Mathematics, Physics & Statistics, University of British Columbia Okanagan, Kelowna, BC, Canada, ⁷Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁸Kinesiology, University of British Columbia, Vancouver, BC, Canada, ⁹Pediatrics, University of British Columbia, Vancouver, BC, Canada, ¹⁰Physical Therapy, University of British Columbia, Vancouver, BC, Canada

Myelin water imaging (MWI) provides quantitative and specific mapping of myelin content in-vivo. Water trapped between myelin bilayers have a short T₂ relaxation time; the fractional proportion of this myelin water signal correlates strongly with histological staining for myelin. MWI has successfully been used to study both the brain and spinal cord where it can increase our understanding of development, aging and disease processes, and may also improve accuracy of diagnosis, prognosis and assessment of therapeutic response. Moving forward, MWI is expected to play an important role in the development and monitoring of new treatments targeted at remyelination and neuroprotection.

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