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Abstract #4202

The Review of Age-Related White Matter Changes in Alzheimer’s Disease Trials

Dewen Yang1

1ICON Clinical Research, North Wales, PA, United States

Age-related white matter changes (ARWMC) are prevalent brain imaging findings and important substrates for cognitive impairment in the elderly. The true pathogenesis of ARWMC is not well understood. Previous studies verified that ARWMC also associate with cognitive decline. In Alzheimer’s disease, ARWMC is also common findings on MRI images. The clinical importance of ARWMC in AD trials is reviewed.

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