Abstract #4227

Altered causal connectivity of the anterior cingulate cortex in obsessive compulsive disorder

Fei Li¹, Su Lui¹, Li Yao¹, Xiaoqi Huang¹, Yanchun Yang², and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China, ²Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, People's Republic of China

In order to explore the role of anterior cingulate cortex (ACC) in the pathophysiology of obsessive-compulsive disorder (OCD), we used the resting-state functional magnetic resonance imaging (rfMRI) and Granger causality analysis (GCA) and found that the left pregenual ACC of OCD showed decreased amplitude of low-frequency fluctuation (ALFF) than controls. The areas with altered ALFF exhibited decreased driving effect to right dorsal superior frontal gyrus (dSFG) and left precuneus, and a significant increase in the causal influence from left ventral SFG (vSFG) to the left pregenual ACC in OCD compared to controls.

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