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Abstract #4233

Detecting treatment response of a novel immune stimulator in an animal model of glioblastoma with conventional and cell tracking MRI

Runze Yang1, Susobhan Sarkar2, V. Wee Yong2, and Jeff F Dunn1,2

1Radiology, University of Calgary, Calgary, AB, Canada, 2Clinical Neuroscience, University of Calgary

Glioblastoma Multiforme (GBM) is an aggressive brain cancer. Immunotherapy is a promising avenue of exploration for treatment of GBM. We discovered a new drug capable of stimulating innate immunity and showed that it is able of reducing tumor growth in a mouse model of GBM. We used ultrasmall iron oxide nanoparticles (USPIO) to track the migration of stimulated immune cells and showed that this drug related response can be detected with as little as 7 days of treatment. MRI tracking of immune cells using USPIO is a promising tool that can be easily translated into the clinical setting.

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