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Abstract #4235

MRI Signal Enhancement in Early-Stage GBM Detection by Nonlinear Spin Dynamics using Active Feedback Fields

Huimin Yang1, Chaohsiung Hsu2, and Yung-Ya Lin1

1Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States, 2Chemistry, National Taiwan University, Taipei, Taiwan

Application of MR imaging is very limited in imaging sensitivity and contrast in regards to the detection of brain tumor at an early stage because of tiny variations between healthy tissue and early-stage tumor. The radiation damping effect provides insight about the nonlinear spin evolution. Taking advantage of nonlinear spin evolution, we confirmed theoretically and experimentally that MR imaging provides a more stable and significant contrast in comparison to conventional methods.

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