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Abstract #4242

CEST and binding water MT separation in brain tumor by multi pool model CEST Peak Extraction method

Mitsuharu Miyoshi1, Masafumi Harada2, Yuki Kanazawa2, and Hiroyuki Kabasawa1

1Global MR Applications & Workflow, GE Healthcare Japan, Hino, Tokyo, Japan, 2Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan

Although MTR asymmetry is often used as a CEST parameter, it is not quantitative. In this study, CEST Peak Extraction (CPE) method was used to separate CEST and MT parameters. CEST peaks in brain tumor could be fitted with Lorentzian function on CPE spectrum. Each fitted parameter had a quantitative meaning in multi pool model, which includes CEST pool, binding water MT pool and free water pool.

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