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Abstract #4251

Radiogenomic analysis of distinct tumor sub-compartments on T2 and FLAIR predict distinct molecular subtypes in Lower Grade Gliomas

Niha Beig1, Ramon Correa1, Prateek Prasanna1, Jhimli Mitra1, Ameya Nayate2, Anant Madabhushi1, and Pallavi Tiwari1

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, University Hospitals, Cleveland, OH, United States

The recent categorization of low-grade Glioma (LGG) has been modified based on the molecular aberrations associated with IDH mutations (IDHmut or IDH-WT) and 1p19q co-deletions (codel or non-codel). We explored the utility of radiogenomic analysis to identify radiomics signatures (computer extracted features from MRI) that distinguish IDHmut codel, IDHmut noncodel, and IDH-WT LGG tumors on T2 and FLAIR sequences. Initial results indicate that radiomic features from non-enhancing regions on T2 and infiltrative edges on FLAIR can segregate the 3 subgroups. A non-invasive means of discerning molecular subtypes on MRI may allow clinicians to determine prognosis, and inform treatment strategy.

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