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Abstract #4313

Measurement of Phosphocreatine and BOLD Kinetics in the Lower Extremity Muscles using a Dual-Frequency Coil Array

Ryan Brown1,2, Oleksandr Khegai1,2, and Prodromos Parasoglou1,2

1Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States, 2Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States

MRI provides the unique ability to study metabolic and microvasculature functions in skeletal muscle using phosphorus and proton measurements. However, the low sensitivity of these techniques can make it difficult to capture dynamic muscle activity due to the temporal resolution required for kinetic measurements during and after exercise tasks. We developed a dual-nuclei coil array to enable proton and phosphorus MRI of the human lower extremities with SNR more than double that of a birdcage coil in the gastrocnemius muscles. This enabled the local assessment of phosphocreatine recovery kinetics following a plantar flexion exercise using an efficient sampling scheme with a 6 s temporal resolution. The integrated proton array demonstrated image quality approximately equal to that of a clinical state-of-the-art knee coil, which enabled fat quantification and dynamic blood oxygen level-dependent measurements that reflect microvasculature function.

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