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Abstract #4351

A multi-parametric MRI-based radiomics approach to predict the high level of microsatellite instability in colorectal cancer

Zaiyi Liu1, Yanqi Huang1, Xin Chen2, Zhongping Zhang3, Lan He1, and Xiaomei Huang1

1Radiology, Guangdong General Hospital, Guangzhou, People's Republic of China, 2Radiology, Guangzhou First Hospital, Guangzhou, People's Republic of China, 3MR Research China, GE Healthcare, Beijing, People's Republic of China

Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA mismatch repair (MMR). High levels of microsatellite instability (MSI-H) is regarded as a prognostic marker and predictor of the response to chemotherapy in colorectal cancer (CRC). This study presented a multi-parametric radionics classifier for preoperative and individualized prediction of MSC-H status in CRC patients. The potential application of this radiomics approach may aid the prognostic evaluation and decision-making in CRC patients.

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