Abstract #4351

A multi-parametric MRI-based radiomics approach to predict the high level of microsatellite instability in colorectal cancer

Zaiyi Liu¹, Yanqi Huang¹, Xin Chen², Zhongping Zhang³, Lan He¹, and Xiaomei Huang¹

¹Radiology, Guangdong General Hospital, Guangzhou, People's Republic of China, ²Radiology, Guangzhou First Hospital, Guangzhou, People's Republic of China, ³MR Research China, GE Healthcare, Beijing, People's Republic of China

Microsatellite instability (MSI) is the condition of genetic hypermutability that results from impaired DNA mismatch repair (MMR). High levels of microsatellite instability (MSI-H) is regarded as a prognostic marker and predictor of the response to chemotherapy in colorectal cancer (CRC). This study presented a multi-parametric radionics classifier for preoperative and individualized prediction of MSC-H status in CRC patients. The potential application of this radiomics approach may aid the prognostic evaluation and decision-making in CRC patients.

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