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Abstract #4353

Radiation-induced changes in normal-appearing brain in patients with nasopharyngeal carcinoma: a MR T1ρ imaging study

Xiang Xiao1, Yikai Xu1, Yuankui Wu1, Yingjie Mei2, and Queenie Chan3

1Medical Imaging Center, Nanfang Hospital of Southern Medical University, Guangzhou, People's Republic of China, 2Philips Healthcare, Guangzhou, People's Republic of China, 3Philips Healthcare, Hongkong, People's Republic of China

Radiation encephalopathy is the primary complication in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). In order to detect early radiation-induced alterations in the brain of NPC patients after RT, we recruited NPC patients before RT and after RT with normal-appearing brain for MR T1ρ examinations. We found abnormal microstructural changes of gray matter and white matter in NPC patients after RT can be detected by MR T1ρ even when routine MRI findings are negative. MR T1ρ may be used to predict early radiation-induced alterations of the brain following RT for NPC patients.

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