Abstract #4367

Prediction of Individual Breast Tumor Therapeutic Response

Charles S. Springer, Jr.¹, Xin Li¹, Megan L. Troxell², Karen Y. Oh³, Arpana Naik⁴, Kathleen A. Kemmer⁵, Aneela Afzal¹, May H. Mishal¹, Alina Tudorica³, and Wei Huang¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Pathology, Oregon Health & Science University, Portland, OR, ³Radiology, Oregon Health & Science University, Portland, OR, ⁴Surgical Oncology, Oregon Health & Science University, Portland, OR, ⁵Medical Oncology, Oregon Health & Science University

Synopsis: A k_io parametric image maps Na⁺,K⁺ATPase activity with intra-tumor resolution. For breast tumors, the k_io hot spot fraction decreases after one NACT cycle if the tumor goes on to be cancer-free after NACT completion, but not if it maintains residual cancer. Also, though k_io hot spots are reduced after one NACT cycle, new ones appear in different loci. This is consistent with metabolic competition between different cancer cell populations within the tumor.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.