Abstract #4367

Prediction of Individual Breast Tumor Therapeutic Response

Charles S. Springer, Jr.¹, Xin Li¹, Megan L. Troxell², Karen Y. Oh³, Arpana Naik⁴, Kathleen A. Kemmer⁵, Aneela Afzal¹, May H. Mishal¹, Alina Tudorica³, and Wei Huang¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Pathology, Oregon Health & Science University, Portland, OR, ³Radiology, Oregon Health & Science University, Portland, OR, ⁴Surgical Oncology, Oregon Health & Science University, Portland, OR, ⁵Medical Oncology, Oregon Health & Science University

Synopsis: A k_io parametric image maps Na⁺,K⁺ATPase activity with intra-tumor resolution. For breast tumors, the k_io hot spot fraction decreases after one NACT cycle if the tumor goes on to be cancer-free after NACT completion, but not if it maintains residual cancer. Also, though k_io hot spots are reduced after one NACT cycle, new ones appear in different loci. This is consistent with metabolic competition between different cancer cell populations within the tumor.

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