Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photoabsorbers after irradiation with NIR light. The purpose of this study was to determine whether MRI can monitor the therapeutic effect of NIR-PIT in spontaneously occurring lung cancers that express epidermal growth factor receptor. Tumor volume ratio was inhibited significantly in the NIR-PIT group compared with control group. Thus, MRI can be a useful imaging modality for monitoring the therapeutic effects of NIR-PIT for cancer.
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