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Abstract #4371

Near infrared photoimmunotherapy for lung cancer in a transgenic mouse model evaluated by MRI

Yuko Nakamura1,2, Marcelino Bernardo1, Zoe Weaver Ohler3, Tadanobu Nagaya1, Shuhei Okuyama1, Fusa Ogata1, Peter L. Choyke1, and Hisataka Kobayashi1

1National Cancer Institute, Bethesda, MD, United States, 2Diagnostic Radiology, Hiroshima University, Hiroshima, Japan, 3Frederick National Laboratory for Cancer Research

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with the toxicity induced by photoabsorbers after irradiation with NIR light. The purpose of this study was to determine whether MRI can monitor the therapeutic effect of NIR-PIT in spontaneously occurring lung cancers that express epidermal growth factor receptor. Tumor volume ratio was inhibited significantly in the NIR-PIT group compared with control group. Thus, MRI can be a useful imaging modality for monitoring the therapeutic effects of NIR-PIT for cancer.

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