Abstract #4382

Quantitative Perfusion Imaging in Rectal Cancer – Choice and Influence of the Arterial Input Function to Perfusion Parameters

Tanja Gaa¹, Sonja Sudarski², Lothar R. Schad¹, and Frank G. Zöllner¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Quantitative perfusion analysis in rectal cancer with DCE-MRI is highly dependent on the choice of the arterial input function (AIF). In nineteen patients it was investigated whether the selection affects the quantification of plasma flow (PF) applying with three different perfusion models (fast deconvolution algorithm, two-compartment uptake model, two-compartment exchange model). Results show disagreements in PF between the two AIFs for all three models with significant differences for the two-compartment exchange and uptake model.

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