Abstract #4400

Density Weighted Concentric Rings K-Space Trajectory for 1H MRSI with gradient offset independent adiabatic pulses at 7T

Mark Chiew¹, Wenwen Jiang², Peder Larson^2,3, Brian Burns⁴, Peter Jezzard¹, Albert Thomas⁵, and Uzay E Emir¹

¹Oxford Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom, ²UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, CA, United States, ³Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, ⁴Department of Oncology, University of Oxford, Oxford, United Kingdom, ⁵Department of Radiological Sciences, University of California, Los Angeles, CA, United States

In this study, we have developed and demonstrated a GOIA-semi-LASER sequence with density-weighted (DW)-concentric rings trajectory (CRT) that performs robustly at 7 Tesla and within a clinically feasible acquisition time. DW-CRT has been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with an in-plane resolution of 5×5 mm². Experiments qualitatively demonstrate the advantage of DW-CRT over uniformly-weighted (UW)-CRT in terms of its improved resolution and reduced contamination of spectra from neighboring voxels.

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