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Abstract #4402

Quantitative MRI of extra-ocular muscles in the clinical evaluation of systemic diseases

Luc van Vught1,2, Robert de Meel3, Jedrzej Burakiewicz2, Stijn Genders1, Martine Jager1, Irene Notting1, Jan Verschuuren3, Hermien Kan2, and Jan-Willem Beenakker1,2

1Ophthalmology, LUMC, Leiden, Netherlands, 2Radiology, CJ Gorter center for high field MRI, LUMC, Leiden, Netherlands, 3Neurology, LUMC, Leiden, Netherlands

Current diagnostic tools fail to accurately assess the condition of the eye muscles and orbital fat in ocular diseases. We have developed a high-resolution 7 Tesla quantitative MRI-protocol of the eye and evaluated its clinical value for Graves' orbitopathy and myasthenia gravis. The scan protocol proved to be robust against eye-motion and extra-ocular muscles were easily segmented from the orbital fat. Patient data showed elevated muscle fat fractions for both conditions compared to healthy subjects. Since the method quantifies the condition of the tissues, which otherwise can only be assess via an invasive biopsy, it potentially is an efficient technique to assess treatment response.

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