Summary: Exophthalmos caused by muscle thickening and fat increasing in orbit is the typical symptom in hyperthyroidism, which impairs multiple systems as the auto-immune disease. From this study, we found the increase of percentage of fat and T2* value using the fat quantification analysis package, which indicate the accumulation and differentiation of fat-oriented cells, inflammation cells infiltration and collagen mucous change. Therefore, the characteristics of fat change in orbit can be evaluated by the transverse six-echo proton density fat fraction (PDFF) sequence (mDIXON-quant) technique in early-stage hyperthyroidism without significant manifestation of eyes.
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