Abstract #4445

A Novel Cryogenic Radio-Frequency Probe for High Spatial Resolution Fluorine-19 MRI of Brain Inflammation

Andreas Pohlmann¹, Jason M Millward¹, Paula Ramos Delgado¹, Daniel Marek², Didier Wecker³, Ralph Wissmann³, Helmar Waiczies⁴, Thoralf Niendorf^1,5, and Sonia Wacizies¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, ²Bruker BioSpin AG, Fällanden, Switzerland, ³Bruker BioSpin MRI GmbH, Ettlingen, Germany, ⁴MRI TOOLs GmbH, Berlin, Germany, ⁵Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center, Berlin, Germany

MRI using i.v. administered fluorine-19 loaded nanoparticles (NPs) allows the tracking of inflammatory cell migration. The inherently low SNR limits the precise localization of 19F-labeled inflammatory cells, because large voxel sizes are needed to collect sufficient signal. To overcome this, we show here the first use of a novel 19F cryogenic quadrature RF surface probe at ultrahigh field to substantially boost SNR beyond that of state-of-the-art room temperature RF coils, while facilitating the acquisition of better spatially-resolved images within shorter scan times.

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