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Abstract #4445

A Novel Cryogenic Radio-Frequency Probe for High Spatial Resolution Fluorine-19 MRI of Brain Inflammation

Andreas Pohlmann1, Jason M Millward1, Paula Ramos Delgado1, Daniel Marek2, Didier Wecker3, Ralph Wissmann3, Helmar Waiczies4, Thoralf Niendorf1,5, and Sonia Wacizies1

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Bruker BioSpin AG, Fällanden, Switzerland, 3Bruker BioSpin MRI GmbH, Ettlingen, Germany, 4MRI TOOLs GmbH, Berlin, Germany, 5Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center, Berlin, Germany

MRI using i.v. administered fluorine-19 loaded nanoparticles (NPs) allows the tracking of inflammatory cell migration. The inherently low SNR limits the precise localization of 19F-labeled inflammatory cells, because large voxel sizes are needed to collect sufficient signal. To overcome this, we show here the first use of a novel 19F cryogenic quadrature RF surface probe at ultrahigh field to substantially boost SNR beyond that of state-of-the-art room temperature RF coils, while facilitating the acquisition of better spatially-resolved images within shorter scan times.

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