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Abstract #4449

Gradient Echo vs. Spin Echo MRI to Determine Liver Iron Concentration

Arthur Peter Wunderlich1,2, Holger Cario3, Mario Teigeler1, Meinrad Beer1, and Stefan Andreas Schmidt1

1Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Department of Pediatrics and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

To evaluate an alternative to an established method for liver iron content (LIC) determination based on spin-echo (SE) MRI, we analyzed 195 MRI scans, including both SE and gradient echo (GRE) protocols, of regularly transfused patients suspected for liver iron overload. A relationship was derived between reference LIC obtained by Ferriscan® and GRE data. From this, LIC was determined using GRE acquisitions and these values correlated to reference LIC. Considering the LIC threshold of 80 µmol/g (4.5 mg/g) relevant for therapy, diagnostic accuracy of the GRE approach was quite good, with sensitivity and specificity of 99/98 % compared to Ferriscan®.

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