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Abstract #4461

Voxel-wise meta-analysis of resting-state functional activity in type 2 diabetes

Taiyuan Liu1, Jia Liu2, Wenhui Wang1, Lun Ma1, Xiaoyue Ma1, Shaojie Shi1, Qiyong Gong3, and Meiyun Wang1

1Henan Provincial People’s Hospital, Zhengzhou, People's Republic of China, 2Huazhong University of Science and Technology, Wuhan, People's Republic of China, 3Department of Radiology, West China Hospital of Sichuan University, Zhengzhou, People's Republic of China

Previous studies about resting-state functional activity reported that altered brain activity was demonstrated with type 2 diabetes and their findings were inconsistent ,which have not been quantitatively reviewed. Therefore, we conducted a quantitative meta-analysis including resting-state functional activity studies of patients with type 2 diabetes. Meta-analysis of pooled and subgroup meta-analyses found that type 2 diabetes patients showed abnormal brain activity mainly in default mode network(DMN) and visual-related regions. Our finding supports that type 2 diabetes could lead to diabetic brain activity alterations, which may correlate with cognitive impairment of type 2 diabetes patients.

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