Abstract #4461

Voxel-wise meta-analysis of resting-state functional activity in type 2 diabetes

Taiyuan Liu¹, Jia Liu², Wenhui Wang¹, Lun Ma¹, Xiaoyue Ma¹, Shaojie Shi¹, Qiyong Gong³, and Meiyun Wang¹

¹Henan Provincial People’s Hospital, Zhengzhou, People's Republic of China, ²Huazhong University of Science and Technology, Wuhan, People's Republic of China, ³Department of Radiology, West China Hospital of Sichuan University, Zhengzhou, People's Republic of China

Previous studies about resting-state functional activity reported that altered brain activity was demonstrated with type 2 diabetes and their findings were inconsistent ,which have not been quantitatively reviewed. Therefore, we conducted a quantitative meta-analysis including resting-state functional activity studies of patients with type 2 diabetes. Meta-analysis of pooled and subgroup meta-analyses found that type 2 diabetes patients showed abnormal brain activity mainly in default mode network(DMN) and visual-related regions. Our finding supports that type 2 diabetes could lead to diabetic brain activity alterations, which may correlate with cognitive impairment of type 2 diabetes patients.

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