Tumor interstitial fluid (TIF) contains the secretome of cancers that can impact most phenotypic aspects of cancer. One characteristic phenotype of pancreatic ductal carcinoma (PDAC) is its ability to induce profound weight loss or cachexia through a multifactorial syndrome that affects multiple organs. To understand the interaction between cancer cells and body organs, here, for the first time, we have characterized the metabolomic profile of TIF from cachexia and non-cachexia inducing pancreatic cancer xenografts and identified clear differences in the metabolic secretome between cachexia inducing and the non-cachexia inducing tumors.
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