Glioblastoma (GBM) is the most common aggressive primary brain tumour in adults and characterization of response to treatment turns out to be crucial for improving patient survival. In this work we obtained 3D-like information, from preclinical GBM under temozolomide (TMZ) treatment, with a multi-slice MRSI approach using source-based nosological images as response biomarker. A “Tumour Response Index” (TRI) was defined as the percentage of responding tumor pixels divided by the total tumour pixels. Heterogeneous response patterns with cyclical longitudinal variations were observed in several mice while responding pixels were mostly seen at the first 2 upper grids.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords