Abstract #4514

Therapeutic Effect of Bone Marrow Stromal Cells on Vascular Permeability and Hemodynamic Alteration in Traumatic Injured Brain: A long-term MRI Study

Lian Li¹, Michael Chopp^1,2, Guangliang Ding¹, Changsheng Qu³, Qingjiang Li¹, Asim Mahmood³, and Quan Jiang^1,2

¹Neurology, Henry Ford Health System, Detroit, MI, United States, ²Physics, Oakland University, Rochester, MI, United States, ³Neurosurgery, Henry Ford Health System, Detroit, MI, United States

Cerebral vascular permeability and hemodynamic alteration in a broad normal appearing brain tissue in response to the transplantation of hMSCs after TBI were longitudinally investigated up to 3-months post-injury. Our data reveal the evidence that a quicker recovery of vascular integrity, as a result of cell transplantation, is associated with a higher level of cerebral perfusion, and acute cell administration after TBI significantly promotes these global therapeutic effects. The findings of the current study indicate that BBB reconstitution plays an essential role in CBF restoration in the injured brain, which in turn, contributes to the improvement of functional outcome.

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