Abstract #4530

Characterizing White Matter Microstructural Changes After Mild Traumatic Brain Injury Based On Diffusion White Matter Tract Integrity And Shannon Entropy

Sohae Chung^1,2, Els Fieremans^1,2, Xiuyuan Wang^1,2, Dmitry S. Novikov^1,2, Farng-Yang A. Foo³, Steven R. Flanagan⁴, and Yvonne W. Lui^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Department of Neurology, New York University Langone Medical Center, New York, NY, United States, ⁴Department of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States

Mild traumatic brain injury (MTBI) is a growing public health problem and some patients may suffer from long-term symptoms. This study shows that there are both microstructural changes as well as regional textural changes after MTBI affecting the corpus callosum within 4 weeks of injury. We demonstrate the potential for compartment specific white matter tract integrity (WMTI) metrics such as tortuosity of the extra-axonal space (a marker of misalignment of fibers or demyelination), and Shannon entropy (reflecting complexity or uncertainty) to be useful as early biomarkers of MTBI-related WM injury.

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