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Abstract #4534

TBI Patients with Cerebral Microhemorrhage Exhibit Increased Magnetic Susceptibility in the Cerebral Hemispheres, but Reduced Magnetic Susceptibility in the Basal Ganglia

Wei Liu1,2, Gerard Riedy1, Ping-Hong Yeh1,2, Dominic E. Nathan1,2, Grant H. Bonavia1, and John Ollinger1

1National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, United States, 2The NorthTide Group, LLC, Dulles, VA, United States

Magnetic susceptibilities of the basal ganglia, as well as the right and left cerebral hemispheres of TBI patients with cerebral microhemorrhage (CMH) were analyzed. Compared to patients without CMH and controls, patients with CMH demonstrated increased magnetic susceptibility in both the left and right hemispheres but decreased magnetic susceptibility in the basal ganglia. This finding suggests disrupted brain iron hemostatsis due to CMH in the chronic phase of TBI.

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