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Abstract #4536

Chronically elevated Taurine in the putative seizure onset zone during posttraumatic epileptogenesis identifies epilepsy-prone rats

Riikka Johanna Immonen1, Amna Yasmin1, Asla Pitkänen1, and Olli Gröhn1

1Neurobiology, A.I.Virtanen Institute, Univ. Eastern Finland, Kuopio, Finland

In lateral fluid percussion rat model for posttraumatic epilepsy 50% of animals have slowly developed epilepsy 1 year after the head injury.1 The seizures presumably originate in the perilesional cortex that appears normal in conventional MRI.2 We targeted localized magnetic resonance spectroscopy (MRS) to this cortical area 6 months post-injury, and found elevated Taurine and elevated macromolecule concentration to differentiate the subpopulation (19%) of injured animals with higher susceptibility to seizures in EEG recorded PTZ test. The preliminary immunohistochemical analysis of the underlying complex pathology revealed swollen neurons that may associate with the increase of osmoregulator taurine.

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