Abstract #4541

Single-scan, whole-brain functional network mapping using optogenetic fMRI with CBV

Andrew J Weitz¹, ManKin Choy², Ben A Duffy², Jia Liu², and Jin Hyung Lee^1,2,3,4

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ³Neurosurgery, Stanford University, Stanford, CA, United States, ⁴Electrical Engineering, Stanford University, Stanford, CA, United States

Optogenetic fMRI studies have traditionally required significant scan averaging to achieve signal-to-noise ratios sufficient for whole-brain functional network mapping. As a result, more scan time is required, and measurements may not directly translate to accompanying behavioral paradigms that employ a single stimulation. Here, we used a SPION-based MRI contrast agent to enable single-scan functional network mapping with CBV during optogenetic stimulation of the thalamic submedial nucleus. Measurement of CBV led to significant activations detected at the site of stimulation and downstream mono- and polysynaptically connected regions. In comparison, single-scan BOLD measurements led to minimal detectable responses to stimulation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.