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Abstract #4541

Single-scan, whole-brain functional network mapping using optogenetic fMRI with CBV

Andrew J Weitz1, ManKin Choy2, Ben A Duffy2, Jia Liu2, and Jin Hyung Lee1,2,3,4

1Bioengineering, Stanford University, Stanford, CA, United States, 2Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, 3Neurosurgery, Stanford University, Stanford, CA, United States, 4Electrical Engineering, Stanford University, Stanford, CA, United States

Optogenetic fMRI studies have traditionally required significant scan averaging to achieve signal-to-noise ratios sufficient for whole-brain functional network mapping. As a result, more scan time is required, and measurements may not directly translate to accompanying behavioral paradigms that employ a single stimulation. Here, we used a SPION-based MRI contrast agent to enable single-scan functional network mapping with CBV during optogenetic stimulation of the thalamic submedial nucleus. Measurement of CBV led to significant activations detected at the site of stimulation and downstream mono- and polysynaptically connected regions. In comparison, single-scan BOLD measurements led to minimal detectable responses to stimulation.

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