Abstract #4549

Validation of inhomogeneous Magnetization Transfer (ihMT) as a myelin biomarker

Valentin H Prevost¹, Olivier M Girard¹, Myriam Cayre², Gopal Varma³, Samira Mchinda¹, Jean-Philippe Ranjeva¹, Jean Pelletier⁴, Pascale Durbec², David C Alsop³, and Guillaume Duhamel¹

¹Aix Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France, ²Aix Marseille Univ, CNRS, IBDM, UMR 7288, Marseille, France, ³Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁴Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

The ihMT (inhomogeneous Magnetization transfer) signal qualitatively demonstrates sensitivity for myelinated structures. However, image intensity and contrast vary with the saturation parameters, further questioning the specificity of ihM for myelin. This study validated ihMT as a myelin biomarker by demonstrating for various ihMT sequences, linear relationships between ihMT signal and intensity of fluorescence microscopy (a quantitative myelin specific histology technique) collected in plp-GFP mouse brain.

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