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Abstract #4549

Validation of inhomogeneous Magnetization Transfer (ihMT) as a myelin biomarker

Valentin H Prevost1, Olivier M Girard1, Myriam Cayre2, Gopal Varma3, Samira Mchinda1, Jean-Philippe Ranjeva1, Jean Pelletier4, Pascale Durbec2, David C Alsop3, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France, 2Aix Marseille Univ, CNRS, IBDM, UMR 7288, Marseille, France, 3Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 4Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

The ihMT (inhomogeneous Magnetization transfer) signal qualitatively demonstrates sensitivity for myelinated structures. However, image intensity and contrast vary with the saturation parameters, further questioning the specificity of ihM for myelin. This study validated ihMT as a myelin biomarker by demonstrating for various ihMT sequences, linear relationships between ihMT signal and intensity of fluorescence microscopy (a quantitative myelin specific histology technique) collected in plp-GFP mouse brain.

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