Abstract #4552

Hippocampal stiffness in mesial temporal sclerosis epilepsy measured by MR elastography: Initial results

Daniel R Smith¹, Hillary Schwarb², Ryan Pohlig³, William C Oliviero^4,5, Bradley P Sutton⁴, Tracey M Wszalek^4,5, Graham R Huesman^4,5,6, and Curtis L Johnson¹

¹Biomedical Engineering, University of Delaware, Newark, DE, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, ³College of Health Sciences, University of Delaware, Newark, DE, United States, ⁴Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Carle Neuroscience Institute, Carle Foundation Hospital, Urbana, IL, United States, ⁶Department of Molecular and Integrative Physiology, Univerity of Illinois Urbana-Champaign, Urbana, IL, United States

Mesial temporal sclerosis (MTS), or hippocampal sclerosis, is the most common form of temporal lobe epilepsy and can be effectively treated by surgery if it is able to be reliably detected. In this work we examine whether hippocampal stiffness measured by magnetic resonance elastography (MRE) is sensitive to MTS. In our preliminary sample of five patients with MTS and seven controls, we found the hippocampus to be softer bilaterally in MTS (-13.4% and -15.2% differences for affected and unaffected sides). This preliminary evidence suggests MRE may provide highly sensitive markers that could aid the diagnosis and treatment of MTS.

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