The primary objective of this longitudinal study is to determine the rate of ipsilesional and contralesional lateral ventricular volume (LVv) enlargement in six mild chronic ischemic stroke patients who underwent serial brain MRI at four time points over one year. Infarct volumes, National Institutes of Health Stroke Scale (NIHSS), LVv, gray matter volume (GMv) and white matter volume (WMv) were also measured. Our results show the ipsilesional increase in LVv and the decrease in WMv suggests post-stroke progression of unilateral atrophy. These changes appear to be independent of the decrease in NIHSS during this same period. This study suggests that MRI can detect pathology that is not reflected by NIHSS.