We applied Neurite Orientation Dispersion and Density Imaging (NODDI) and neurophysiological batteries to 13 patients with moyamoya disease (10 females, age 16-61 yo). We found that intracellular volume fraction (Vic) and orientation dispersion index (OD) decreased as the stages of vascular lesion progressed, and many neurocognitive tasks correlated with the decrease in Vic and OD among different parts of brain. Interestingly, some tasks were much more correlated with the Vic and OD among posterior part of brain than among frontal part. This finding may suggest the importance of PCA lesions in neurocognitive disturbance in patients with moyamoya disease.
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