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Abstract #4584

NODDI revealed the brain microstructural damage in patients with moyamoya disease

Shoko Hara1,2, Masaaki Hori1, Syo Murata1, Ryo Ueda1, Misaki Nakazawa1, Yoji Tanaka2, Taketoshi Maehara2, Shigeki Aoki1, and Tadashi Nariai2

1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan

We applied Neurite Orientation Dispersion and Density Imaging (NODDI) and neurophysiological batteries to 13 patients with moyamoya disease (10 females, age 16-61 yo). We found that intracellular volume fraction (Vic) and orientation dispersion index (OD) decreased as the stages of vascular lesion progressed, and many neurocognitive tasks correlated with the decrease in Vic and OD among different parts of brain. Interestingly, some tasks were much more correlated with the Vic and OD among posterior part of brain than among frontal part. This finding may suggest the importance of PCA lesions in neurocognitive disturbance in patients with moyamoya disease.

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